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Complement Inhibitor Shows Promise for Rare Kidney Disorder

Source link : https://www.newshealth.biz/health-news/complement-inhibitor-shows-promise-for-rare-kidney-disorder/ SAN DIEGO — Intravenous ravulizumab (Ultomiris) yielded clinically meaningful reductions in IgA nephropathy-related proteinuria in a small, mid-stage trial. The 43 patients treated with ravulizumab had a 33.2% greater reduction in average urine protein to creatinine ratio (UPCR) compared with the 22 patients on placebo (P=0.0011), reported James Tumlin, MD, of […]

What Is the Optimal Reliever Therapy for Difficult-to-Control Asthma?

Source link : https://www.newshealth.biz/health-news/what-is-the-optimal-reliever-therapy-for-difficult-to-control-asthma/ BOSTON — Inhaled corticosteroids (ICS) combined either with formoterol (Foradil) or short-acting beta-agonists (SABA) for asthma treatment were associated with reduced risks of severe exacerbations compared with bronchodilator-only relievers, a meta-analysis showed. Compared with bronchodilator-only relievers, “high certainty” evidence showed that ICS-formoterol was associated with an absolute 10.3% lower risk of […]

Obesity May Raise Risk of Long COVID in Youth

Source link : https://www.newshealth.biz/health-news/obesity-may-raise-risk-of-long-covid-in-youth/ Elevated body mass index (BMI) in children and young adults was associated with an increased risk of post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, a large retrospective cohort study suggested. Those with obesity had a 25.4% increased risk of long COVID (relative risk [RR] 1.25, 95% CI 1.06-1.48) and […]

Flu viruses are made to move through mucous

Source link : https://www.newshealth.biz/health-news/flu-viruses-are-made-to-move-through-mucous/ Proteins on the outside of influenza A viruses are key to breaching our bodies’ mucous barriers Kateryna Kon/Science Photo Library Before viruses can infect cells, they must first get to them, often by traversing layers of the body’s protective mucous. Understanding how evolution optimised the influenza A virus for this slimy […]

Prenatal Cannabis Exposure Linked to Poor Executive Function, Aggression in Kids

Source link : https://www.newshealth.biz/health-news/prenatal-cannabis-exposure-linked-to-poor-executive-function-aggression-in-kids/ Poor executive function and aggressive behavior at age 5 years was observed among children exposed to cannabis during pregnancy, a cohort study suggested. Among 250 children, age-corrected standard scores for attention and inhibitory control on the NIH Toolbox Early Childhood Cognitive Composite were about 0.4 standard deviations lower for those exposed […]

Major Win for Preemptive TAVR in Symptomless Aortic Stenosis

Source link : https://www.newshealth.biz/health-news/major-win-for-preemptive-tavr-in-symptomless-aortic-stenosis/ Transcatheter aortic valve replacement (TAVR) yielded clinical benefit when given early in the disease process while patients still had no symptoms or other indication for aortic valve replacement, according to the EARLY TAVR trial. In older people with asymptomatic severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF), upfront […]

Study: Medicare’s Competitive Bidding Program Not a Danger to COPD Oxygen Users

Source link : https://www.newshealth.biz/health-news/study-medicares-competitive-bidding-program-not-a-danger-to-copd-oxygen-users/ The Medicare Competitive Bidding Program (CBP) appeared to reduce spending without impacting oxygen prescriptions for beneficiaries with chronic obstructive pulmonary disease (COPD), a study showed. Implementation of the CBP in two cohorts was not associated with a greater change in probability of a new oxygen prescription (difference in differences [DID] estimate […]

A Look at the Supreme Court’s Upcoming Term

Source link : https://www.newshealth.biz/health-news/a-look-at-the-supreme-courts-upcoming-term/ Gostin is an expert in health law and policy. Radhakrishnan is a law fellow. In the last few years, the Supreme Court has significantly undermined public health powers related to pandemic threats, gun violence, and the environment, while upending decades-old precedents to severely limit reproductive rights and disempower health, safety, and […]

Daylight Saving Ends Next Weekend: How to Prepare for the Potential Health Effects

Source link : https://www.newshealth.biz/health-news/daylight-saving-ends-next-weekend-how-to-prepare-for-the-potential-health-effects/ The good news: You will get a glorious extra hour of sleep. The bad: It’ll be dark as a pocket by late afternoon for the next few months in the U.S. Daylight saving time ends at 2 a.m. local time next Sunday, November 3, which means you should set your clock […]

Hospitals’ AI Transcription Tool Invents Things No One Ever Said, Researchers Say

Source link : https://www.newshealth.biz/health-news/hospitals-ai-transcription-tool-invents-things-no-one-ever-said-researchers-say/ Tech behemoth OpenAI has touted its artificial intelligence-powered transcription tool Whisper as having near “human level robustness and accuracy.” But Whisper has a major flaw: It is prone to making up chunks of text or even entire sentences, according to interviews with more than a dozen software engineers, developers, and academic […]

More Evidence Avatar Therapy Quiets Auditory Hallucinations

Source link : https://www.newshealth.biz/health-news/more-evidence-avatar-therapy-quiets-auditory-hallucinations/ A novel digital treatment designed to reduce the frequency of auditory hallucinations and associated distress in patients with psychosis has been shown to be safe and effective, results from the largest study of avatar therapy to date show.  The therapy allows patients to interact with a “digital embodiment” of the voice […]

Remote Patient Monitoring Is a Great Idea. But What’s the Best Way to Use It?

Source link : https://www.newshealth.biz/health-news/remote-patient-monitoring-is-a-great-idea-but-whats-the-best-way-to-use-it/ Fred Pelzman is an associate professor of medicine at Weill Cornell, and has been a practicing internist for nearly 30 years. He is medical director of Weill Cornell Internal Medicine Associates. I am a huge fan of remote patient monitoring. As I’ve written about before, patients spend a tiny fraction of […]

Fertility rate in England and Wales drops to new low

Source link : https://www.newshealth.biz/health-news/fertility-rate-in-england-and-wales-drops-to-new-low/ Getty Images Just over 591,000 babies were born in the UK last year – the lowest number in four decades Women in England and Wales had an average of 1.44 children between 2022 and 2023, the lowest rate on record. Only 591,072 babies were born in 2023, fewer than in any […]

FDA Requests More Info on PharmaTher’s Ketamine Application

Source link : https://www.newshealth.biz/health-news/fda-requests-more-info-on-pharmathers-ketamine-application/ The US Food and Drug Administration (FDA) has issued a complete response letter (CRL) to PharmaTher citing deficiencies in the company’s abbreviated new drug application for racemic ketamine (Ketarx), the company said.  “The deficiencies cited in the CRL are classified as minor,” the company said in a statement.  “The FDA requested […]

Battle Continues Over Compounded GLP-1s

Source link : https://www.newshealth.biz/health-news/battle-continues-over-compounded-glp-1s/ The US Food and Drug Administration (FDA) has notified compounding pharmacies that the agency — at least temporarily — won’t take action against them for creating copies of the dual glucagon-dependent insulinotropic polypeptide/glucagon-like peptide 1 (GLP-1) drug tirzepatide (Eli Lilly and Company). Meanwhile, Novo Nordisk, which makes semaglutide, has asked the […]

Can Pembrolizumab Improve dMMR Endometrial Cancer Outcomes?

Source link : https://www.newshealth.biz/health-news/can-pembrolizumab-improve-dmmr-endometrial-cancer-outcomes/ TOPLINE: Adding pembrolizumab to adjuvant chemotherapy in the first-line setting improved disease-free survival (DFS) in patients with high-risk endometrial cancer who have mismatch repair–deficient (dMMR) tumors, according to a subgroup analysis of a phase 3 study. METHODOLOGY: About 25%-30% of patients with endometrial cancer harbor dMMR tumors, an inflamed phenotype that […]

Trump and Eugenics; Doctors Poised to Strike; Laced Pizza Sickens Dozens

Source link : https://www.newshealth.biz/health-news/trump-and-eugenics-doctors-poised-to-strike-laced-pizza-sickens-dozens/ Note that some links may require registration or subscription. When former president Donald Trump talks about the “bad genes” of undocumented immigrants, experts hear rhetoric from the eugenics movement. (STAT) If elected to a second term, Trump said he would let Robert F. Kennedy Jr. “go wild” on health, medicine, and […]

FDA Announces Recall of More than 7000 Bottles of Duloxetine

Source link : https://www.newshealth.biz/health-news/fda-announces-recall-of-more-than-7000-bottles-of-duloxetine/ The US Food and Drug Administration (FDA) has announced a voluntary manufacturer-initiated recall of more than 7000 bottles of duloxetine delayed-release capsules due to unacceptable levels of a potential carcinogen. Duloxetine (Cymbalta) is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, chronic musculoskeletal pain, and […]

Maternal BMI and Eating Disorders Tied to Mental Health in Kids

Source link : https://www.newshealth.biz/health-news/maternal-bmi-and-eating-disorders-tied-to-mental-health-in-kids/ TOPLINE: Children of mothers who had obesity or eating disorders before or during pregnancy may face higher risks for neurodevelopmental and psychiatric disorders. METHODOLOGY: Researchers conducted a population-based cohort study to investigate the association of maternal eating disorders and high prepregnancy body mass index (BMI) with psychiatric disorder and neurodevelopmental diagnoses […]

Weight Loss Drugs Don’t Reduce Oocyte Retrieval

Source link : https://www.newshealth.biz/health-news/weight-loss-drugs-dont-reduce-oocyte-retrieval/ The use of glucagon-like peptide 1 (GLP-1) agonists within a year had no apparent effect on the number of oocytes retrieved in controlled ovarian hyperstimulation (COH), based on data from 73 patients in a multicenter study. Obesity rates continue to rise in women of reproductive age and many women are using […]

PCPs less likely to prescribe nonantibiotic options for UTI

Source link : https://www.newshealth.biz/health-news/pcps-less-likely-to-prescribe-nonantibiotic-options-for-uti/ While primary care physicians are generally comfortable prescribing vaginal estrogen therapy for recurrent urinary tract infections (UTIs), other nonantibiotic prophylactic options remain significantly underutilized, according to new research that highlights a crucial gap in antibiotic stewardship practices among primary care physicians. UTIs are the most common bacterial infection in women of […]

Does AI-Assisted Colonoscopy Help Find Advanced Neoplasia?

Source link : https://www.newshealth.biz/health-news/does-ai-assisted-colonoscopy-help-find-advanced-neoplasia/ A new meta-analysis confirms that use of computer-aided detection (CADe) systems during colonoscopy finds more polyps and adenomas than conventional colonoscopy, but the effect on detection of advanced colorectal neoplasia (ACN) remains unclear. The research team, which focused on advanced neoplasia due to their clinical importance, found a small increase in […]

Old Drug a New Option for Stroke-Related Aphasia?

Source link : https://www.newshealth.biz/health-news/old-drug-a-new-option-for-stroke-related-aphasia/ Abu Dhabi, UAE — Cerebrolysin, a porcine-derived collection of growth factors already employed for a broad array of neurodegenerative disorders in Asia and Eastern Europe, was effective for stroke-related aphasia, the results of a double-blind, randomized controlled trial showed. The study demonstrated that the drug, when used alongside speech therapy, led […]

Can Stem Cells Relieve Chronic Low Back Pain?

Source link : https://www.newshealth.biz/health-news/can-stem-cells-relieve-chronic-low-back-pain/ TOPLINE: Allogeneic bone marrow–derived mesenchymal stromal cells (BM-MSCs) are safe but do not show efficacy in treating intervertebral disc degeneration (IDD) in patients with chronic low back pain. METHODOLOGY: The RESPINE trial assessed the efficacy and safety of a single intradiscal injection of allogeneic BM-MSCs in the treatment of chronic low […]

Should Pharmacists Lead BP Control Teams?

Source link : https://www.newshealth.biz/health-news/should-pharmacists-lead-bp-control-teams/ Current efforts to control high blood pressure (BP) are failing in the United States and globally. The first World Health Organization (WHO) global report on hypertension found that, globally, only 54% of adults with hypertension are diagnosed, 42% get treatment, and just 21% have their hypertension controlled. In the United States, […]

US Veterans May Face Nearly Triple the Risk for Skin Cancer

Source link : https://www.newshealth.biz/health-news/us-veterans-may-face-nearly-triple-the-risk-for-skin-cancer/ US veterans were nearly three times more likely to develop skin cancer than the general population, according to a large cross-sectional analysis of recent national data. Sepideh Ashrafzadeh, MD “US veterans are known to have increased risk of cancers and cancer morbidity compared to the general US population,” one of the […]

Screen Time Removal Before Bed Can Improve Sleep in Toddlers

Source link : https://www.newshealth.biz/health-news/screen-time-removal-before-bed-can-improve-sleep-in-toddlers/ TOPLINE: Taking screens away from toddlers an hour before bedtime resulted in slight improvements in sleep; however, this intervention did not have a significant impact on attention measures. METHODOLOGY: The randomized clinical trial aimed to evaluate the feasibility and efficacy of a 7-week, parent-administered screen time intervention (PASTI) in toddlers aged […]

Anaphylaxis Uncertainty Persists for Patients and Professionals

Source link : https://www.newshealth.biz/health-news/anaphylaxis-uncertainty-persists-for-patients-and-professionals/ Misinformation and outdated protocols contribute to the suboptimal management of anaphylaxis by patients and healthcare professionals, based on data from two new studies presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting. Anaphylaxis can strike suddenly, and many patients and caregivers at risk do not know which […]

Can We Repurpose Obesity Drugs to Reverse Liver Disease?

Source link : https://www.newshealth.biz/health-news/can-we-repurpose-obesity-drugs-to-reverse-liver-disease/ Metabolic dysfunction–associated steatotic liver disease (MASLD) has become the most common liver disease worldwide, with a global prevalence of 32.4%. Its growth over the past three decades has occurred in tandem with increasing rates of obesity and type 2 diabetes — two cornerstones of MASLD. Higher rates of MASLD and metabolic […]

How close were hospitals to collapse in Covid?

Source link : https://www.newshealth.biz/health-news/how-close-were-hospitals-to-collapse-in-covid/ BBC Five times Prof Kevin Fong broke down in tears in a nondescript hearing room in West London, while giving evidence to the Covid inquiry. The 53-year-old has the kind of CV that makes you pay attention: a consultant anaesthetist in London who also works for the air ambulance service and […]

Doctor who urinated in Gosport hospital sink struck off

Source link : https://www.newshealth.biz/health-news/doctor-who-urinated-in-gosport-hospital-sink-struck-off/ Getty Images Two colleagues said they had seen Dr Graham Holmes urinating into a sink A doctor found to have urinated in a consultation room’s sink and failed to adhere to restrictions on his registration has been struck off. Graham Holmes worked as a locum consultant in Hampshire, Dorset, Greater Manchester […]

Humans and Carbs: A Complicated 800,000-Year Relationship

Source link : https://www.newshealth.biz/health-news/humans-and-carbs-a-complicated-800000-year-relationship/ Trying to reduce your carbohydrate intake means going against nearly a million years of evolution. Humans are among a few species with multiple copies of certain genes that help us break down starch — carbs like potatoes, beans, corn, and grains — so that we can turn it into energy our […]

Rising Stroke Rates in Californians With SCD

Source link : https://www.newshealth.biz/health-news/rising-stroke-rates-in-californians-with-scd/ TOPLINE: Stroke rates in Californians with sickle cell disease (SCD) have increased in both children and adults in the post-STOP era. The cumulative incidence of first ischemic stroke was 2.1% by age 20 and 13.5% by age 60. METHODOLOGY: Researchers analyzed data from the California Department of Health Care Access and […]

Study Compares Methods for Treating Recalcitrant Keloids

Source link : https://www.newshealth.biz/health-news/study-compares-methods-for-treating-recalcitrant-keloids/ Punch excision (PE) followed by immediate cryotherapy could be a viable and simpler alternative to core excision (CE) for the treatment of recalcitrant keloids, according to the results of a small retrospective study. Jinwoong Jung, MD The method “offers similar efficacy, faster healing, and fewer complications,” one of the study authors, […]

Upadacitinib Effective Long Term for AD in Adolescents

Source link : https://www.newshealth.biz/health-news/upadacitinib-effective-long-term-for-ad-in-adolescents/ TOPLINE: Long-term treatment with upadacitinib in adolescents with moderate to severe atopic dermatitis (AD) demonstrated sustained efficacy and an acceptable safety profile through 76 weeks across three phase 3 trials. METHODOLOGY: Researchers conducted three double-blind, placebo-controlled phase 3 randomized clinical trials (Measure Up 1, Measure Up 2, and AD Up) involving […]

Empagliflozin Effects Subside With Discontinuation

Source link : https://www.newshealth.biz/health-news/empagliflozin-effects-subside-with-discontinuation/ SAN DIEGO — The significant kidney and cardiovascular benefits people with chronic kidney disease (CKD) show over 2 years of treatment with empagliflozin begin to subside within about a year after treatment discontinuation, suggesting the need for ongoing treatment. “We know that empagliflozin is safe we know it works and now […]

Dupilumab Proves Effective in Chronic Spontaneous Urticaria

Source link : https://www.newshealth.biz/health-news/dupilumab-proves-effective-in-chronic-spontaneous-urticaria/ BOSTON — Add-on dupilumab (Dupixent) significantly reduced itching and urticaria in patients with chronic spontaneous urticaria (CSU) whose symptoms were uncontrolled with H1-antihistamine therapy. The phase III LIBERTY-CUPID study C showed that among children and adults randomized to receive either dupilumab or placebo added to standard-of-care (SoC) H1 antihistamines, those receiving […]

Interim ALIGN Data: Atrasentan Cuts Proteinuria in IgA Nephropathy

Source link : https://www.newshealth.biz/health-news/interim-align-data-atrasentan-cuts-proteinuria-in-iga-nephropathy/ SAN DIEGO — A novel drug significantly reduced IgA nephropathy-related proteinuria, according to interim findings of the ALIGN study. In the phase III trial, among 270 patients with the rare kidney disorder, those on atrasentan had a 36.1 percentage point (95% CI -44.6 to -26.4, PAmerican Society of Nephrology Kidney Week […]

‘This Was Not a Rare or Exceptional Circumstance’: What We Heard This Week

Source link : https://www.newshealth.biz/health-news/this-was-not-a-rare-or-exceptional-circumstance-what-we-heard-this-week/ “It became clear to me that this was not a rare or exceptional circumstance, but that the overwhelming majority of youth receiving this care were happy with it.” — Kristina Olson, PhD, of Princeton University, reporting that most youth who received gender-affirming care had no regrets. “We really should be looking […]

Mortality Rates From Early-Onset CRC Have Risen Considerably

Source link : https://www.newshealth.biz/health-news/mortality-rates-from-early-onset-crc-have-risen-considerably/ PHILADELPHIA — The mortality rate of early-onset colorectal cancer (EO-CRC) has increased considerably across the United States over the past two decades, with the effects most pronounced in those aged 20-44 years, according to a new analysis of the two largest US mortality databases.  Data from the US Centers for Disease […]

PBM Math: Big Chains Get $23.55 for Blood Pressure Rx as Small Drugstores Get $1.51

Source link : https://www.newshealth.biz/health-news/pbm-math-big-chains-get-23-55-for-blood-pressure-rx-as-small-drugstores-get-1-51/ CUTHBERT, Ga. — While customers at Adams Family Pharmacy picked up their prescriptions on a hot summer day, some stopped in for coffee, ice cream, homemade cake, or cookies. It wasn’t a bake sale, but the sweets bring extra revenue as pharmacist and co-owner Nikki Bryant, PharmD, works to achieve profitability […]

Going Beyond Hearing Aids for Equal Care Access

Source link : https://www.newshealth.biz/health-news/going-beyond-hearing-aids-for-equal-care-access/ Huang is a family physician who is fluent in American Sign Language (ASL). As a physician who is hard of hearing, I was excited to learn about FDA’s authorization of Apple’s newest AirPods, which will come with the capability to convert into hearing aids. If the AirPods live up to their […]

Dapagliflozin Safe and Effective in CKD Stages 4 and 5

Source link : https://www.newshealth.biz/health-news/dapagliflozin-safe-and-effective-in-ckd-stages-4-and-5/ SAN DIEGO — Dapagliflozin provides significant benefits in the treatment of chronic kidney disease (CKD) even when initiated in patients with the most severe stages of the disease who are typically excluded from clinical trials, new research shows. In patients with CKD stage 4-5, dapagliflozin plus integrated CKD care improved total […]

Alternative Pathway Inhibition Makes Good in IgA Nephropathy

Source link : https://www.newshealth.biz/health-news/alternative-pathway-inhibition-makes-good-in-iga-nephropathy/ SAN DIEGO — There was a clinically meaningful reduction in proteinuria with iptacopan (Fabhalta), and a confirmed clinical benefit of alternative pathway inhibition, in a rare kidney disorder, according to an interim analysis of the APPLAUSE-IgAN study. In the phase III study, among the first 250 patients with IgA nephropathy who […]

Did CDC Recommend a Second Dose of the New COVID Vaccine for All Adults?

Source link : https://www.newshealth.biz/health-news/did-cdc-recommend-a-second-dose-of-the-new-covid-vaccine-for-all-adults/ The 24-hour news cycle is just as important to medicine as it is to politics, finance, or sports. At MedPage Today, new information is posted daily, but keeping up can be a challenge. As an aid for our readers, and for a little amusement, here is a 10-question quiz based on […]

Pediatric Febrile UTI May Hurt Kidney Function

Source link : https://www.newshealth.biz/health-news/pediatric-febrile-uti-may-hurt-kidney-function/ SAN DIEGO — Antibiotic prophylaxis may help to protect kidneys of kids with vesicoureteral reflux during febrile urinary tract infections (UTIs), according to another look at the RIVUR trial. Among 188 children with this common congenital anomaly, more than one febrile UTI during the 2-year study period had an average eGFR […]

Metformin and Congenital Abnormalities; Deprescribing in Patients With Dementia

Source link : https://www.newshealth.biz/health-news/metformin-and-congenital-abnormalities-deprescribing-in-patients-with-dementia/ TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. This week’s topics include […]

AKI Intervention Falls Short of Improving Patient Outcomes

Source link : https://www.newshealth.biz/health-news/aki-intervention-falls-short-of-improving-patient-outcomes/ SAN DIEGO — A strategy to improve the management of hospitalized patients with acute kidney injury (AKI) through rapid personalized recommendations made by a dedicated kidney action team facilitates testing and other measures, but ultimately falls short in improving clinical outcomes, a randomized, multicenter study shows. Although recommendations from a dedicated […]

I’m a Black Trauma Surgeon. Ending Gun Violence Demands Fighting for Racial Justice.

Source link : https://www.newshealth.biz/health-news/im-a-black-trauma-surgeon-ending-gun-violence-demands-fighting-for-racial-justice/ Williams is a trauma surgeon. Eighteen months ago, we buried my cousin — shot dead in front of his house. In the heat of my congressional campaign, time to mourn conflicted with fundraising, meet-and-greets, and securing endorsements. On the campaign trail, running on a gun safety platform, I shared stories about […]

Limited Kidney Benefits With Finerenone in Heart Failure

Source link : https://www.newshealth.biz/health-news/limited-kidney-benefits-with-finerenone-in-heart-failure/ SAN DIEGO — In patients with heart failure, treatment with finerenone provides some benefits in reducing the risk for macroalbuminuria. However, no significant changes are observed in estimated glomerular filtration rate (eGFR)-based kidney outcomes, an analysis of the recently published FINEARTS-HF trial shows. “Among patients with heart failure with mildly reduced […]

Precision Medicine Approach Shows Promise for Anaplastic Thyroid Cancer

Source link : https://www.newshealth.biz/health-news/precision-medicine-approach-shows-promise-for-anaplastic-thyroid-cancer/ Two prospective trials of immunotherapy in thyroid cancer, one of them negative, provided support for precision-medicine approaches that include immunotherapy. A trial of atezolizumab (Tecentriq) and mutation-selected targeted agents led to better overall survival (OS) as compared with historical results in anaplastic thyroid carcinoma (ATC), reaching a maximum of 43 months […]

At Least 75 People Sickened as Deadly McDonald’s E. Coli Outbreak Expands

Source link : https://www.newshealth.biz/health-news/at-least-75-people-sickened-as-deadly-mcdonalds-e-coli-outbreak-expands/ A deadly outbreak of Escherichia coli poisoning tied to McDonald’s Quarter Pounders has expanded, with at least 75 people sick in 13 states, federal health officials said Friday. A total of 22 people have now been hospitalized, and two have developed a dangerous kidney disease complication, the CDC said. One person […]

FDA Approves Novel Treatment for UTIs

Source link : https://www.newshealth.biz/health-news/fda-approves-novel-treatment-for-utis/ The FDA approved oral sulopenem etzadroxil and probenecid (Orlynvah) to treat uncomplicated urinary tract infections (uUTIs) caused by certain bacteria in women with limited or no alternative oral antibacterial treatment options, the agency said Friday. The drug is a combination of a penem antibacterial (sulopenem etzadroxil) and a renal tubular transport […]

Upadacitinib Shows Long-Term Benefits in Teens With Atopic Dermatitis

Source link : https://www.newshealth.biz/health-news/upadacitinib-shows-long-term-benefits-in-teens-with-atopic-dermatitis/ Treatment with the Janus kinase (JAK) inhibitor upadacitinib (Rinvoq) showed a favorable long-term benefit-risk profile through 76 weeks in adolescents with moderate to severe atopic dermatitis, an analysis of three phase III randomized trials showed. At week 76 in the Measure Up 1, Measure Up 2, and AD Up trials, 84-89% […]

Algorithm May Be Able to Predict HCC Risk in Advanced Chronic Liver Disease

Source link : https://www.newshealth.biz/health-news/algorithm-may-be-able-to-predict-hcc-risk-in-advanced-chronic-liver-disease/ A risk stratification algorithm may be able to predict which patients with advanced chronic liver disease are at risk of developing hepatocellular carcinoma (HCC), according to a large-scale multicenter study. Among more than 2,300 patients with advanced chronic liver disease, a six-parameter algorithm, known as PLEASE, indicated that patients stratified as […]

His Death Would Not Be a Good Death

Source link : https://www.newshealth.biz/health-news/his-death-would-not-be-a-good-death/ Listen and subscribe/follow on Apple and Spotify so you don’t miss the next episode. And if you like what you hear, a five-star rating goes a long way in helping us share the story side of medicine! This story is from the Anamnesis episode called A Moral Code: Ethical Dilemmas in […]

A Moral Code: Ethical Dilemmas in Medicine

Source link : https://www.newshealth.biz/health-news/a-moral-code-ethical-dilemmas-in-medicine/ Listen and subscribe to Anamnesis by searching for MedPod Today on Apple and Spotify so you don’t miss the next episode. Amy Ho: Hey everyone and welcome back to Anamnesis by MedPage. Now, I’m Amy Ho: ER doctor, lover of stories, and your humble podcast host. We are back for another […]

Stroke Survivors With Afib Could Start DOACs Earlier

Source link : https://www.newshealth.biz/health-news/stroke-survivors-with-afib-could-start-doacs-earlier/ It was safe to start direct oral anticoagulant (DOAC) therapy without delay after acute ischemic stroke in people with atrial fibrillation (Afib), according to the OPTIMAS randomized trial. Stroke survivors randomized to early or delayed DOAC initiation had the same 3.3% incidence of composite recurrent ischemic stroke, symptomatic intracranial hemorrhage, unclassifiable […]

MHRA Warns of Weight Loss Drug Side Effects

Source link : https://www.newshealth.biz/health-news/mhra-warns-of-weight-loss-drug-side-effects/ The Medicines and Healthcare products Regulatory Agency (MHRA) has reminded healthcare professionals to warn patients about common and serious side effects associated with glucagon-like peptide-1 receptor agonists (GLP-1RAs).  Simultaneously, the House of Lords food, diet, and obesity committee declared a public health emergency on obesity and diet-related diseases and recommended a […]

Novel Research Details Incidence of Ploidy Abnormalities

Source link : https://www.newshealth.biz/health-news/novel-research-details-incidence-of-ploidy-abnormalities/ DENVER — Genetic testing and algorithms revealed that over 1% of more than 96,000 blastocyst-stage embryos had ploidy abnormalities, or atypical numbers of chromosomes. In total, ploidy abnormalities were detected in 1.15% (CI 95% 1.0-1.2) of embryos after clinical pre-implantation genetic testing, of which 0.9% were triploidy (embryos with an extra […]

Personalized Breast Cancer Treatment; Insights Into HPV in Men; Exercise and Cancer

Source link : https://www.newshealth.biz/health-news/personalized-breast-cancer-treatment-insights-into-hpv-in-men-exercise-and-cancer/ Surgical innovations for breast cancer have led to personalized treatment choices that are more complex than lumpectomy versus mastectomy. (Mayo Clinic) Using a breast cancer’s genetic signature to guide treatment showed promise for improving outcomes in a phase III trial. (The BMJ) Use of artificial intelligence guidance did not improve the […]

Kidney Transplant Trouble Spelled Out for Newer Rejection Episode Categories

Source link : https://www.newshealth.biz/health-news/kidney-transplant-trouble-spelled-out-for-newer-rejection-episode-categories/ SAN DIEGO — Kidney transplant patients who shifted into newly recognized microvascular inflammation categories under revised definitions had an intermediate risk of poor allograft outcomes, a large study showed. Researchers examined outcomes among more than 6,700 kidney transplant recipients, looking at two categories added in 2022 to the benchmark diagnostic framework […]

Traumatic Fractures Surge Among US Mountain Bikers

Source link : https://www.newshealth.biz/health-news/traumatic-fractures-surge-among-us-mountain-bikers/ TOPLINE: Mountain biking–related fractures have surged since 2013 in the United States, with wrist and radius or ulnar injuries being most common; adult men are at the highest risk for trunk fractures, and being thrown from the bike is the mechanism most likely to result in a fracture. METHODOLOGY: Researchers analyzed […]

Online IVF Injection Training Boosts Patient Confidence

Source link : https://www.newshealth.biz/health-news/online-ivf-injection-training-boosts-patient-confidence/ DENVER — Online training about the details of in vitro fertilization (IVF) boosts patient confidence about managing the process more than in-person training, according to research presented on October 21 at the 2024 Scientific Conference & Expo of the American Society for Reproductive Medicine (ASRM).  “It can take quite a bit […]

Europe’s Polio-Free Status Is Not a Done Deal

Source link : https://www.newshealth.biz/health-news/europes-polio-free-status-is-not-a-done-deal/ The European Regional Commission for the Certification of Poliomyelitis Eradication (RCC) has warned that Europe’s long-held polio-free status could be at risk due to inadequately enforced and outdated action plans for potential outbreaks. Vaccine manufacturing premises are a specific concern. “While there is notable progress with implementation of the WHO Global […]

This surprisingly creative trick helps children eat more fruit and veg

Source link : https://www.newshealth.biz/health-news/this-surprisingly-creative-trick-helps-children-eat-more-fruit-and-veg/ Weaving tales of magical fruit and vegetables into your children’s stories may encourage them to eat healthy snacks Source link : https://www.newscientist.com/article/2453306-this-surprisingly-creative-trick-helps-children-eat-more-fruit-and-veg/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=health Author : Publish date : 2024-10-25 14:00:00 Copyright for syndicated content belongs to the linked Source. Author : News Health Publish date : 2024-10-25 14:00:00 Copyright for syndicated content […]

GLP-1s May Protect Against Progression to Cirrhosis in MASLD

Source link : https://www.newshealth.biz/health-news/glp-1s-may-protect-against-progression-to-cirrhosis-in-masld/ TOPLINE: For patients with metabolic dysfunction–associated steatotic liver disease (MASLD) and diabetes, treatment with a glucagon-like peptide 1 receptor agonist (GLP-1 RA) may protect against progression to cirrhosis and mortality; however, the protective benefits do not extend to patients who already have cirrhosis, a new study found. METHODOLOGY: GLP-1 RAs reduce […]

Landiolol Reduces and Maintains Heart Rate in Septic Shock

Source link : https://www.newshealth.biz/health-news/landiolol-reduces-and-maintains-heart-rate-in-septic-shock/ TOPLINE: Landiolol reduces and maintains heart rate for 24 hours without increasing the need for vasopressors in patients with septic shock and persistent tachycardia. METHODOLOGY: Researchers conducted a multicenter, randomized, open-label, controlled trial in 196 intensive care unit (ICU) adult patients with septic shock and persistent tachycardia at 20 sites in […]

A Case of Broca’s Aphasia

Source link : https://www.newshealth.biz/health-news/a-case-of-brocas-aphasia/ Schwartz is a neurosurgeon. On Sept. 14, 2000, at the age of 72, Lester Schwartz, a psychoanalyst working in New York City, underwent a simple operation for a benign fatty tumor in his stomach. He woke up the next morning in the hospital and realized he had lost his ability to […]

New Data on DOAC Initiation After Stroke in AF: Final Word?

Source link : https://www.newshealth.biz/health-news/new-data-on-doac-initiation-after-stroke-in-af-final-word/ Abu Dhabi, UAE — The long-standing debate as to when to start anticoagulation in patients with an acute ischemic stroke and atrial fibrillation (AF) looks as though it’s settled. Results of the OPTIMAS trial, the largest trial to address this question, showed that initiation of a direct oral anticoagulant (DOAC) within […]

Travel Nurses Still in Demand

Source link : https://www.newshealth.biz/health-news/travel-nurses-still-in-demand/ Ashly Doran has worked at seven hospitals in four states since she graduated from nursing school in 2020. No, she isn’t job-hopping. Her travel nursing assignments have ranged from level 1 trauma center emergency rooms in big cities to small medical-surgical units in the suburbs. After each 13-week assignment, Doran packs […]

Traumatic Brain Injury Leads to Labor Market Consequences

Source link : https://www.newshealth.biz/health-news/traumatic-brain-injury-leads-to-labor-market-consequences/ Across Canada, patients who sustain traumatic brain injury (TBI) face potential unemployment and thousands of dollars of personal income loss in the years following their injury, according to a new study. By the third year, significant income loss was seen regardless of injury severity. It ranged from about $3350 CAD (or […]

Uncertainty Over Balloon Guide Catheter Use for MT in Stroke

Source link : https://www.newshealth.biz/health-news/uncertainty-over-balloon-guide-catheter-use-for-mt-in-stroke/ Abu Dhabi, UAE — Use of a balloon guide catheter was associated with worse functional outcomes than use of a conventional guide catheter in stroke patients with large vessel anterior occlusions undergoing thrombectomy within 24 hours of symptom onset  However, the PROTECT-MT trial was stopped early, and the small sample size […]

Does Exercise Intensity Modulate Ghrelin?

Source link : https://www.newshealth.biz/health-news/does-exercise-intensity-modulate-ghrelin/ TOPLINE:  High-intensity exercise suppresses ghrelin levels more than moderate-intensity exercise, leading to a greater reduction in hunger. This effect may be more pronounced in women than in men. METHODOLOGY: Ghrelin circulates in acylated and deacylated forms and is associated with hunger perceptions. Previous studies have indicated that acute exercise can modulate […]

Parent Perceptions Drive Diets of Children With AD

Source link : https://www.newshealth.biz/health-news/parent-perceptions-drive-diets-of-children-with-ad/ Approximately one third of parents of children with atopic dermatitis (AD) reported little or no improvement with elimination diets, and nearly 80% reintroduced the eliminated foods, based on survey data from nearly 300 parents. Although AD can be associated with an increased risk for food allergies, major allergy organizations do not […]

WHO Growth Curves Misclassify Inuit Children

Source link : https://www.newshealth.biz/health-news/who-growth-curves-misclassify-inuit-children/ Using population-specific growth curves for Inuit children could promote the appropriate diagnosis of microcephaly and avoid overdiagnosis, according to a new study. Inuit children from Nunavut, Canada, may appear to have high rates of macrocephaly, based on World Health Organization (WHO) growth chart measurements. But in many cases, no pathology is […]

Digital Tool May Help Neurologists Assess Steroid Toxicity

Source link : https://www.newshealth.biz/health-news/digital-tool-may-help-neurologists-assess-steroid-toxicity/ SAVANNAH, Ga. — A digital tool to help neurologists assess steroid toxicity in patients with myasthenia gravis (MG) demonstrated sensitivity in distinguishing between different doses and durations of steroid exposure in a retrospective, real-world study. The Glucocorticoid Toxicity Index-Metabolic Domains (GTI-MD), an abbreviated version of the GTI (Steritas), used weighted, standardized […]

Veterans Affairs Hailed as a ‘Bright Spot’ in ALS Care

Source link : https://www.newshealth.biz/health-news/veterans-affairs-hailed-as-a-bright-spot-in-als-care/ SAVANNAH, GEORGIA — Teamwork and transdisciplinary collaboration create an effective system of care for amyotrophic lateral sclerosis (ALS), ensuring improved health both for patients and clinicians alike, said one expert. In a plenary address on October 17 at the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) 2024, Ileana Howard, MD, […]

Can Vaccines Slash Global Antibiotic Use? WHO Says Yes

Source link : https://www.newshealth.biz/health-news/can-vaccines-slash-global-antibiotic-use-who-says-yes/ Expanding vaccine use has the potential to reduce the administration of up to 2.5 billion doses of antimicrobials per year, making a significant contribution to the fight against antimicrobial resistance (AMR), one of the greatest public health challenges worldwide. This information is included in a new World Health Organization (WHO) report […]

Investigational Drug Shows Signal to Protect Rods and Cones

Source link : https://www.newshealth.biz/health-news/investigational-drug-shows-signal-to-protect-rods-and-cones/ CHICAGO — An investigational drug that would potentially be the third approved treatment for people with geographic atrophy has demonstrated a signal the two approved treatments have not: An ability to protect photoreceptors in the eye from further damage. Rahul Khurana, MD Geographic atrophy causes the loss of photoreceptors, the rod […]

OnabotulinumtoxinA Approved for Treatment of Platysma Bands

Source link : https://www.newshealth.biz/health-news/onabotulinumtoxina-approved-for-treatment-of-platysma-bands/ The US Food and Drug Administration (FDA) has approved onabotulinumtoxinA (Botox Cosmetic) for temporary improvement in the appearance of moderate to severe platysma bands in adults. According to a press release from Allergan Aesthetics, which developed onabotulinumtoxinA, by injecting along the jawline and the vertical bands connecting the jaw and neck […]

Pioneering eyebrow surgery removes large brain tumours

Source link : https://www.newshealth.biz/health-news/pioneering-eyebrow-surgery-removes-large-brain-tumours/ BBC Doreen Adams said she was grateful to have been able to receive the new surgery Pioneering surgery to remove large brain tumours through the eyebrows of patients has been successfully carried out in Scotland. In what has been described as a “world first”, NHS Grampian said tumours the size of […]

ACIP Votes to ‘Harmonize’ Dosing and Interval for Meningococcal B Vaccines

Source link : https://www.newshealth.biz/health-news/acip-votes-to-harmonize-dosing-and-interval-for-meningococcal-b-vaccines/ The CDC’s Advisory Committee on Immunization Practices (ACIP) on Thursday unanimously endorsed revising the dosing and interval of the meningococcal group B vaccine MenB-4C (Bexsero). In a 15-0 vote, ACIP recommended that MenB-4C be administered as a two-dose series at 0 and 6 months when given to healthy adolescents and young […]

Ozempic Linked With Lower Risk of Alzheimer’s Diagnosis

Source link : https://www.newshealth.biz/health-news/ozempic-linked-with-lower-risk-of-alzheimers-diagnosis/ Semaglutide was linked with reduced Alzheimer’s risk among people with diabetes. The drug outperformed seven other diabetes medications in an observational study. GLP-1 drugs may target multiple Alzheimer’s pathways, including inflammation. Semaglutide (Ozempic) was tied to a reduced risk of Alzheimer’s disease diagnoses in people with type 2 diabetes, observational data […]

GLP-1 Drugs Tied to Reduced Risk of Uterine Fibroids

Source link : https://www.newshealth.biz/health-news/glp-1-drugs-tied-to-reduced-risk-of-uterine-fibroids/ DENVER — In women with type 2 diabetes, use of GLP-1 receptor agonists was associated with a reduced risk of new-onset uterine fibroids compared with other antidiabetic agents, a retrospective cohort study suggested. Among patients who took at least two doses of medication, GLP-1 receptor agonists were associated with a significantly […]

Old-Line Rheum Drugs Lose Luster in JIA

Source link : https://www.newshealth.biz/health-news/old-line-rheum-drugs-lose-luster-in-jia/ Use of conventional synthetic drugs to treat juvenile idiopathic arthritis (JIA) fell by half during 2000-2022, as targeted therapies became increasingly popular, analysis of commercial insurance claims showed. Whereas 89.5% of new prescriptions for disease-modifying anti-rheumatic drugs (DMARDs) in 2000 were for old-line agents, by the end of the period such […]

FDA Warns Companies Over Products Made With Amniotic Fluid

Source link : https://www.newshealth.biz/health-news/fda-warns-companies-over-products-made-with-amniotic-fluid/ The FDA has sent warning letters to two companies regarding their amniotic membrane- and fluid-derived PalinGen products, charging they should be regulated as drugs and biologics. One of the letters, addressed to Phoenix, Arizona-based Pinnacle Transplant Technologies’ president and chief executive officer Roger W. Rose, claimed the company distributed products derived […]

The Case Against White Coats; Addicted to Nasal Spray? Get Ready for a Shift With Me

Source link : https://www.newshealth.biz/health-news/the-case-against-white-coats-addicted-to-nasal-spray-get-ready-for-a-shift-with-me/ The following contains links to social media websites including X, TikTok, Instagram, Facebook, and LinkedIn. “Just because I don’t wear a white coat doesn’t make me any less of a doctor,” said internist @dr.evab, advocating for comfort and confidence over traditional white coat uniforms. “Who says surgeons and anesthesiologists can’t get […]

No Evidence of Human-to-Human H5N1 Transmission in Missouri Case

Source link : https://www.newshealth.biz/health-news/no-evidence-of-human-to-human-h5n1-transmission-in-missouri-case/ There’s no evidence of human-to-human transmission of H5N1 bird flu among patients and healthcare workers in Missouri, the CDC said during a press briefing today. None of the six healthcare workers who developed respiratory symptoms after coming into contact with an H5N1-infected patient was infected with the virus; one tested negative […]

Use of Lidocaine During Vaginoscopic Hysteroscopy-Guided Biopsy Reduced Pain

Source link : https://www.newshealth.biz/health-news/use-of-lidocaine-during-vaginoscopic-hysteroscopy-guided-biopsy-reduced-pain/ DENVER — For women undergoing endometrial biopsy using vaginoscopic hysteroscopy, intrauterine lidocaine significantly decreased pain during and after the procedure, a double-blinded randomized trial showed. Women randomized to lidocaine reported significantly less pain using a visual analogue scale (VAS) at hysteroscope insertion; during the biopsy; and at 10, 30, and 60 […]

UVA Health Surgeons Sound Alarm on Upcoding

Source link : https://www.newshealth.biz/health-news/uva-health-surgeons-sound-alarm-on-upcoding/ More light has been shed on allegations of a toxic work environment at the University of Virginia School of Medicine and UVA Health. About a year ago, surgeons had raised concerns that they were pressured by leadership to upcode in an effort to bring in more money, according to The Daily […]

Approval of Bevacizumab Biosimilar Could Eliminate Access to Low-Cost AMD Therapy

Source link : https://www.newshealth.biz/health-news/approval-of-bevacizumab-biosimilar-could-eliminate-access-to-low-cost-amd-therapy/ CHICAGO — Availability of a bevacizumab biosimilar for ophthalmic use could eliminate a lower-cost treatment option for a wide variety of off-label indications and add hundreds of millions of dollars in healthcare costs, according to a study reported here. Bevacizumab-vikg for ophthalmic use has been submitted for FDA approval. A positive […]

Doctors warn people not to ignore rash

Source link : https://www.newshealth.biz/health-news/doctors-warn-people-not-to-ignore-rash/ Getty Images Scabies can lead to secondary skin infections, if not treated. People are being told not to ignore an itchy rash, with GPs in England reporting a spike in scabies – the highly infectious skin infestation. The condition is caused by a mite which burrows under the skin to lay […]

Emerging Fungal Infections Demand All-Out Approach

Source link : https://www.newshealth.biz/health-news/emerging-fungal-infections-demand-all-out-approach/ As the number of drug-resistant and other troublesome tinea infections grows, perhaps the only certainty is that these are not the tinea subtypes that most providers studied in medical school. As dermatologists, public health officials, and infectious disease specialists scramble to raise awareness about prevention and treatment, challenges ranging from a […]

How Much Should Doctors Give to Charity?

Source link : https://www.newshealth.biz/health-news/how-much-should-doctors-give-to-charity/ This question we are going to address today is a loaded and very personal one. The question is: How much should we give to charity? Everyone must determine the answer to this for themselves. However, one could argue that as high-income earners, doctors have a greater obligation. My wife Selenid and […]

Medicaid Expansion Linked to Better Survival in Aggressive Breast Cancer

Source link : https://www.newshealth.biz/health-news/medicaid-expansion-linked-to-better-survival-in-aggressive-breast-cancer/ Women with newly diagnosed hormone receptor (HR)-negative, HER2-positive breast cancer were more likely to receive timely treatment and have longer survival in states that participated in Medicaid expansion under the Affordable Care Act, a nationwide study showed. For over 31,000 women with this aggressive breast cancer, Medicaid expansion was associated with […]

Gene-Editing Therapy Reduced Attacks in Hereditary Angioedema

Source link : https://www.newshealth.biz/health-news/gene-editing-therapy-reduced-attacks-in-hereditary-angioedema/ A single dose of the CRISPR-based gene-editing therapy NTLA-2002 reduced angioedema attacks and led to sustained reduction in total plasma kallikrein protein levels compared with placebo in patients with hereditary angioedema, a phase II randomized trial showed. From week 1 to week 16 among 27 patients, the estimated mean monthly angioedema […]

Doc’s COVID Spending Bust; Plastic Surgeon Faces $10M Suit; Letby Loses Appeal

Source link : https://www.newshealth.biz/health-news/docs-covid-spending-bust-plastic-surgeon-faces-10m-suit-letby-loses-appeal/ Washington state dermatologist William Philip Werschler, MD, has been indicted on charges that he used $1.5 million in COVID relief funds to buy sports cars, real estate, and pay off personal debt. (KREM) A woman has filed a $10 million lawsuit against New York plastic surgeon Ammar Mahmoud, MD, alleging he […]

50 Years After City Halted Prison Medical Testing, Families Seek Reparations

Source link : https://www.newshealth.biz/health-news/50-years-after-city-halted-prison-medical-testing-families-seek-reparations/ Fifty years ago, Philadelphia prison officials ended a medical testing program that had allowed an Ivy League researcher to conduct human testing on incarcerated people, many of them Black, for decades. Now, survivors of the program and their descendants want reparations. Thousands of people at Holmesburg Prison were exposed to painful […]

Potential Drivers of LCINS

Source link : https://www.newshealth.biz/health-news/potential-drivers-of-lcins/ The incidence of lung cancer in never-smokers (LCINS) is increasing, and experts think climate change may be driving this. LCINS differs histologically and epidemiologically from smoking-related cancers, occurring almost always as adenocarcinomas and mostly affecting women and individuals of Asian ancestry, according to a study published in Nature Reviews Clinical Oncology […]

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